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1,4 Dioxane: Unraveling the Complexity of the Method Choices

Event Announcement

Tuesday, Oct 15, 2019

About This Webinar:

1,4-Dioxane has come under increasing regulatory scrutiny as concerns regarding its toxicity (as a carcinogen) and potential impact on drinking water supplies has increased.  As a consequence of increasing concern regarding human exposure, accurate determination of 1,4-Dioxane at previously unachievable detection limits (< 1 ppb) is now required. The requirement for accuracy at low detection limits creates significant challenges for both the analytical laboratory and data users, which are fundamentally attributed to the high water solubility of 1,4-Dioxane.  This high water solubility makes 1,4-Dioxane difficult to determine by historical analytical techniques such as EPA Methods 8260 and 8270.  Consequently, analytical laboratories have modified these conventional methods with a wide range of enhancements to improve the reliability and sensitivity of the base method.  Modifications include use of solid phase extraction instead of conventional liquid/liquid extraction, selected ion monitoring mass spectrometry instead of ‘full scan’ acquisition, isotope dilution quantitation instead of internal standard quantitation, large volume injection, micro-extraction, and a variety of others.  These modifications can be ‘mixed and matched’ with each other, and meanwhile the historical base methods are also still in use for this analyte.  These circumstances lead to a bewildering array of analytical options with a range of performance characteristics. This presentation will deconvolute the analytical permutations and focus on the most desirable modifications for specific data quality objectives.  Data users and project managers will understand the pros and cons of major method enhancements and how they are combined to provide the most cost-effective method for project-specific data quality objectives.


Topics Presented:

  • General Regulatory Overview
  • Current methods choices for 1,4 Dioxane
  • Review of Method SW-846 for Method 8260 for 1,4 Dioxane
  • Review of Methods SW-846 for Method 8270 for 1,4 Dioxane 
  • All the method permutations reviewed


Who Should Attend?

  • Consulting and Engineering firms
  • Industry Representatives
  • Regulatory Officials
  • Data Validators 


A question and answer session will immediately follow the presentation. At the conclusion of each webinar, you will be asked for your feedback and opinions for future webinar topics to be developed by TestAmerica.

Tuesday, October 15, 2019