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1,4 Dioxane: Unraveling the Complexity of the Method Choices

Event Announcement

Tuesday, Jul 28, 2020

About This Webinar:

1,4-Dioxane has come under increasing regulatory scrutiny as concerns regarding its toxicity (as a carcinogen) and potential impact on drinking water supplies has increased. As a consequence of increasing concern regarding human exposure, accurate determination of 1,4-Dioxane at previously unachievable detection limits is now required.

The requirement for accuracy at low detection limits creates significant challenges for both the analytical laboratory and data users, which are fundamentally attributed to the high water solubility of 1,4-Dioxane. This high water solubility makes 1,4-Dioxane difficult to determine by historical analytical techniques such as EPA Methods 8260 and 8270. Consequently, analytical laboratories have modified these conventional methods with a wide range of enhancements to improve the reliability and sensitivity of the base method.

Modifications include use of solid phase extraction instead of conventional liquid/liquid extraction, selected ion monitoring mass spectrometry instead of ‘full scan’ acquisition, isotope dilution quantitation instead of internal standard quantitation, large volume injection, micro-extraction, and a variety of others. These modifications can be ‘mixed and matched’ with each other, and meanwhile the historical base methods are also still in use for this analyte.

These circumstances lead to a bewildering array of analytical options with a range of performance characteristics. This presentation will deconvolute the analytical permutations and focus on the most desirable modifications for specific data quality objectives. Data users and project managers will understand the pros and cons of major method enhancements and how they are combined to provide the most cost-effective method for project-specific data quality objectives.

A question and answer session will immediately follow the presentation. At the conclusion of each webinar, you will be asked for your feedback and opinions for future webinar topics to be developed by Eurofins Environment Testing America (EETA).

July 28, 2020